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Therapeutic and prophylactic deletion of IL‐4Ra‐signaling ameliorates established ovalbumin induced allergic asthma

BACKGROUND: Allergic asthma is a chronic inflammatory airway disease driven predominantly by a T(H)2 immune response to environmental allergens. IL‐4Rα‐signaling is essential for driving T(H)2‐type immunity to allergens. Anti‐T(H)2 therapies have the potential to effectively reduce airway obstructio...

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Detalhes bibliográficos
Publicado no:Allergy
Main Authors: Khumalo, Jermaine, Kirstein, Frank, Scibiorek, Martyna, Hadebe, Sabelo, Brombacher, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318634/
https://ncbi.nlm.nih.gov/pubmed/31782803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.14137
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