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Therapeutic and prophylactic deletion of IL‐4Ra‐signaling ameliorates established ovalbumin induced allergic asthma

BACKGROUND: Allergic asthma is a chronic inflammatory airway disease driven predominantly by a T(H)2 immune response to environmental allergens. IL‐4Rα‐signaling is essential for driving T(H)2‐type immunity to allergens. Anti‐T(H)2 therapies have the potential to effectively reduce airway obstructio...

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Vydáno v:Allergy
Hlavní autoři: Khumalo, Jermaine, Kirstein, Frank, Scibiorek, Martyna, Hadebe, Sabelo, Brombacher, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318634/
https://ncbi.nlm.nih.gov/pubmed/31782803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.14137
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