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IL-4Rα signaling in CD4(+)CD25(+)FoxP3(+) T regulatory cells restrains airway inflammation via limiting local tissue IL-33
Impaired tolerance to innocuous particles during allergic asthma has been linked to increased plasticity of FoxP3(+) regulatory T cells (Tregs) reprogramming into pathogenic effector cells, thus exacerbating airway disease. However, failure of tolerance mechanisms is driven by Th2 inflammatory signa...
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| Pubblicato in: | JCI Insight |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7605533/ https://ncbi.nlm.nih.gov/pubmed/32931477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136206 |
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