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Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a
[Image: see text] CRISPR-Cas12a is a genome-editing system, recently also harnessed for nucleic acid detection, which is promising for the diagnosis of the SARS-CoV-2 coronavirus through the DETECTR technology. Here, a collective ensemble of multimicrosecond molecular dynamics characterizes the key...
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| Vydáno v: | J Chem Inf Model |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical
Society
2020
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7605327/ https://ncbi.nlm.nih.gov/pubmed/33107304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.0c00929 |
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