Chylomicronemia from GPIHBP1 autoantibodies

Some cases of chylomicronemia are caused by autoantibodies against glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial cell protein that shuttles LPL to the capillary lumen. GPIHBP1 autoantibodies prevent binding and transport of LPL by GPIHBP1, thereby disrupting t...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: Miyashita, Kazuya, Lutz, Jens, Hudgins, Lisa C., Toib, Dana, Ashraf, Ambika P., Song, Wenxin, Murakami, Masami, Nakajima, Katsuyuki, Ploug, Michael, Fong, Loren G., Young, Stephen G., Beigneux, Anne P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604722/
https://ncbi.nlm.nih.gov/pubmed/32948662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R120001116
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