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The NLRP3 inflammasome in macrophages is stimulated by cell‐free hemoglobin

Cell‐free hemoglobin (CFH) is associated with severe lung injury in human patients and is sufficient to induce airspace inflammation and alveolar–capillary barrier dysfunction in an experimental model of acute lung injury. The mechanisms through which this occurs are unknown. One key pathway which r...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Shaver, Ciara M., Landstreet, Stuart R., Pugazenthi, Sangamithra, Scott, Fiona, Putz, Nathan, Ware, Lorraine B., Bastarache, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601531/
https://ncbi.nlm.nih.gov/pubmed/33128438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14589
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