Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis

Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported that cell-free hemoglobin (CFH), elevated in 80% of p...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Meegan, Jamie E., Shaver, Ciara M., Putz, Nathan D., Jesse, Jordan J., Landstreet, Stuart R., Lee, Han Noo Ri, Sidorova, Tatiana N., McNeil, J. Brennan, Wynn, James L., Cheung-Flynn, Joyce, Komalavilas, Padmini, Brophy, Colleen M., Ware, Lorraine B., Bastarache, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996826/
https://ncbi.nlm.nih.gov/pubmed/32012200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228727
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