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Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis

Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported that cell-free hemoglobin (CFH), elevated in 80% of p...

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Publicat a:PLoS One
Autors principals: Meegan, Jamie E., Shaver, Ciara M., Putz, Nathan D., Jesse, Jordan J., Landstreet, Stuart R., Lee, Han Noo Ri, Sidorova, Tatiana N., McNeil, J. Brennan, Wynn, James L., Cheung-Flynn, Joyce, Komalavilas, Padmini, Brophy, Colleen M., Ware, Lorraine B., Bastarache, Julie A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996826/
https://ncbi.nlm.nih.gov/pubmed/32012200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228727
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