Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis

Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported that cell-free hemoglobin (CFH), elevated in 80% of p...

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Pubblicato in:PLoS One
Autori principali: Meegan, Jamie E., Shaver, Ciara M., Putz, Nathan D., Jesse, Jordan J., Landstreet, Stuart R., Lee, Han Noo Ri, Sidorova, Tatiana N., McNeil, J. Brennan, Wynn, James L., Cheung-Flynn, Joyce, Komalavilas, Padmini, Brophy, Colleen M., Ware, Lorraine B., Bastarache, Julie A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996826/
https://ncbi.nlm.nih.gov/pubmed/32012200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228727
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