Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca(2+) or Mg(2+): Hints to Understand Protein Activity

The guanylyl cyclase-activating protein 1, GCAP1, activates or inhibits retinal guanylyl cyclase (retGC) depending on cellular Ca(2+) concentrations. Several point mutations of GCAP1 have been associated with impaired calcium sensitivity that eventually triggers progressive retinal degeneration. In...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Bonì, Francesco, Marino, Valerio, Bidoia, Carlo, Mastrangelo, Eloise, Barbiroli, Alberto, Dell’Orco, Daniele, Milani, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600425/
https://ncbi.nlm.nih.gov/pubmed/33027977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10101408
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