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Allosteric communication pathways routed by Ca(2+)/Mg(2+) exchange in GCAP1 selectively switch target regulation modes

GCAP1 is a neuronal calcium sensor protein that regulates the phototransduction cascade in vertebrates by switching between activator and inhibitor of the target guanylate cyclase (GC) in a Ca(2+)-dependent manner. We carried out exhaustive molecular dynamics simulations of GCAP1 and determined the...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Marino, Valerio, Dell’Orco, Daniele
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064319/
https://ncbi.nlm.nih.gov/pubmed/27739433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34277
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