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Allosteric communication pathways routed by Ca(2+)/Mg(2+) exchange in GCAP1 selectively switch target regulation modes
GCAP1 is a neuronal calcium sensor protein that regulates the phototransduction cascade in vertebrates by switching between activator and inhibitor of the target guanylate cyclase (GC) in a Ca(2+)-dependent manner. We carried out exhaustive molecular dynamics simulations of GCAP1 and determined the...
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| Publicado no: | Sci Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5064319/ https://ncbi.nlm.nih.gov/pubmed/27739433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34277 |
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