Completing the Enalaprilat Excretion Pathway—Renal Handling by the Proximal Tubule

Background: Enalapril is often used in the treatment of cardiovascular diseases. Clinical data suggest that the urinary excretion of enalaprilat, the active metabolite of enalapril, is mediated by renal transporters. We aimed to identify enalaprilat specificity for renal proximal tubular transporter...

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Pubblicato in:Pharmaceutics
Autori principali: Smeets, Nori J. L., Litjens, Carlijn H. C., van den Heuvel, Jeroen J. M. W., van Hove, Hedwig, van den Broek, Petra, Russel, Frans G. M., Koenderink, Jan B., de Wildt, Saskia N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600309/
https://ncbi.nlm.nih.gov/pubmed/33007874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12100935
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