Rifampicin Transport by OATP1B1 Variants

Single nucleotide polymorphisms in the OATP1B1 transporter have been suggested to partially explain the large interindividual variation in rifampicin exposure. HEK293 cells overexpressing wild-type (WT) or OATP1B1 variants *1b, *4, *5, and *15 were used to determine the in vitro rifampicin intrinsic...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Litjens, Carlijn H. C., van den Heuvel, Jeroen J. M. W, Russel, Frans G. M., Aarnoutse, Rob E., te Brake, Lindsey H. M., Koenderink, Jan B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2020
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508598/
https://ncbi.nlm.nih.gov/pubmed/32690641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00955-20
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