Moxifloxacin Is a Potent In Vitro Inhibitor of OCT- and MATE-Mediated Transport of Metformin and Ethambutol

It is largely unknown if simultaneous administration of tuberculosis (TB) drugs and metformin leads to drug-drug interactions (DDIs). Disposition of metformin is determined by organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs). Thus, any DDIs would primarily be med...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: te Brake, Lindsey H. M., van den Heuvel, Jeroen J. M. W., Buaben, Aaron O., van Crevel, Reinout, Bilos, Albert, Russel, Frans G., Aarnoutse, Rob E., Koenderink, Jan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118989/
https://ncbi.nlm.nih.gov/pubmed/27645247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01471-16
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