The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling

AIMS: Endocannabinoids are lipid mediators involved in the regulation of glucose homeostasis. They interact with the canonical cannabinoid receptors CB(1) and CB(2), and it is now apparent that some cannabinoid receptor ligands are also agonists at GPR55. Thus, CB(1) antagonists such as SR141716A, a...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Ruz-Maldonado, Inmaculada, Liu, Bo, Atanes, Patricio, Pingitore, Attilio, Huang, Guo Cai, Choudhary, Pratik, Persaud, Shanta J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599183/
https://ncbi.nlm.nih.gov/pubmed/31925452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03433-6
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