The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling

AIMS: Endocannabinoids are lipid mediators involved in the regulation of glucose homeostasis. They interact with the canonical cannabinoid receptors CB(1) and CB(2), and it is now apparent that some cannabinoid receptor ligands are also agonists at GPR55. Thus, CB(1) antagonists such as SR141716A, a...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Life Sci
Autori principali: Ruz-Maldonado, Inmaculada, Liu, Bo, Atanes, Patricio, Pingitore, Attilio, Huang, Guo Cai, Choudhary, Pratik, Persaud, Shanta J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599183/
https://ncbi.nlm.nih.gov/pubmed/31925452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03433-6
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