T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk

The LncRNA my-heart (Mhrt) and the chromatin remodeler Brg1 inhibit each other to respectively prevent or favor the maladaptive α-myosin-heavy-chain (Myh6) to β-myosin-heavy-chain (Myh7) switch, so their balance crucially guides the outcome of cardiac remodeling under stress conditions. Even though...

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Publicado en:Cells
Autores principales: Forini, Francesca, Nicolini, Giuseppina, Kusmic, Claudia, D’Aurizio, Romina, Mercatanti, Alberto, Iervasi, Giorgio, Pitto, Letizia
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598656/
https://ncbi.nlm.nih.gov/pubmed/32987653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102155
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