The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis

Psoriasis is a frequent, inflammatory skin disease characterized by keratinocyte hyperproliferation and a disease-related infiltration of immune cells. Here, we identified a novel proinflammatory signaling pathway driven by cyclin-dependent kinase 4 (CDK4) and CDK6 and the methyltransferase EZH2 as...

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Pubblicato in:J Clin Invest
Autori principali: Müller, Anne, Dickmanns, Antje, Resch, Claudia, Schäkel, Knut, Hailfinger, Stephan, Dobbelstein, Matthias, Schulze-Osthoff, Klaus, Kramer, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598068/
https://ncbi.nlm.nih.gov/pubmed/32701505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134217
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