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IκBζ is a key transcriptional regulator of IL-36–driven psoriasis-related gene expression in keratinocytes
Proinflammatory cytokine signaling in keratinocytes plays a crucial role in the pathogenesis of psoriasis, a skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes and infiltration of inflammatory cells. Although IL-17A and TNFα are effective therapeutic targe...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176600/ https://ncbi.nlm.nih.gov/pubmed/30224457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801377115 |
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