Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation

The transcriptional activator IκBζ is a key regulator of psoriasis, but which cells mediate its pathogenic effect remains unknown. Here we found that IκBζ expression in keratinocytes triggers not only skin lesions but also systemic inflammation in mouse psoriasis models. Specific depletion of IκBζ i...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Lorscheid, Sebastian, Müller, Anne, Löffler, Jessica, Resch, Claudia, Bucher, Philip, Kurschus, Florian C., Waisman, Ari, Schäkel, Knut, Hailfinger, Stephan, Schulze-Osthoff, Klaus, Kramer, Daniela
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948851/
https://ncbi.nlm.nih.gov/pubmed/31622280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130835
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