Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation

The transcriptional activator IκBζ is a key regulator of psoriasis, but which cells mediate its pathogenic effect remains unknown. Here we found that IκBζ expression in keratinocytes triggers not only skin lesions but also systemic inflammation in mouse psoriasis models. Specific depletion of IκBζ i...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Lorscheid, Sebastian, Müller, Anne, Löffler, Jessica, Resch, Claudia, Bucher, Philip, Kurschus, Florian C., Waisman, Ari, Schäkel, Knut, Hailfinger, Stephan, Schulze-Osthoff, Klaus, Kramer, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948851/
https://ncbi.nlm.nih.gov/pubmed/31622280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130835
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