Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma

Glioblastoma multiforme (GBM) heterogeneity causes a greater number of deaths than any other brain tumor, despite the availability of alkylating chemotherapy. GBM stem-like cells (GSCs) contribute to GBM complexity and chemoresistance, but it remains challenging to identify and target GSCs or factor...

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Pubblicato in:J Clin Invest
Autori principali: Moon, Byoung-San, Cai, Mingyang, Lee, Grace, Zhao, Tong, Song, Xiaofeng, Giannotta, Steven L., Attenello, Frank J., Yu, Min, Lu, Wange
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598052/
https://ncbi.nlm.nih.gov/pubmed/33016927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127916
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