Connexin 43 inhibition sensitizes chemoresistant glioblastoma cells to temozolomide

Resistance of glioblastoma (GBM) to the front-line chemotherapeutic agent temozolomide (TMZ) continues to challenge GBM treatment efforts. The repair of TMZ-induced DNA damage by O-6-methylguanine-DNA methyltransferase (MGMT) confers one mechanism of TMZ resistance. Paradoxically, MGMT-deficient GBM...

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Udgivet i:Cancer Res
Main Authors: Murphy, Susan F, Varghese, Robin T, Lamouille, Samy, Guo, Sujuan, Pridham, Kevin J, Kanabur, Pratik, Osimani, Alyssa M, Sharma, Shaan, Jourdan, Jane, Rodgers, Cara M, Simonds, Gary R, Gourdie, Robert G, Sheng, Zhi
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113032/
https://ncbi.nlm.nih.gov/pubmed/26542214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1286
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