Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

Women with dense breasts have an increased lifetime risk of malignancy that has been attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and mechanical measurements in normal tissue revealed that stroma in the high-density breast contains more oriented, fibrillar c...

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Pubblicato in:J Clin Invest
Autori principali: Northey, Jason J., Barrett, Alexander S., Acerbi, Irene, Hayward, Mary-Kate, Talamantes, Stephanie, Dean, Ivory S., Mouw, Janna K., Ponik, Suzanne M., Lakins, Jonathon N., Huang, Po-Jui, Wu, Junmin, Shi, Quanming, Samson, Susan, Keely, Patricia J., Mukhtar, Rita A., Liphardt, Jan T., Shepherd, John A., Hwang, E. Shelley, Chen, Yunn-Yi, Hansen, Kirk C., Littlepage, Laurie E., Weaver, Valerie M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598051/
https://ncbi.nlm.nih.gov/pubmed/32721948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129249
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