Implication of ZNF217 in accelerating tumor development and therapeutically targeting ZNF217-induced PI3K-AKT signaling for the treatment of metastatic osteosarcoma

We previously identified ZNF217 as an oncogenic driver of a subset of osteosarcomas (OSAs) using the Sleeping Beauty (SB) transposon system. Here, we followed up investigating the genetic role of ZNF217 in OSA initiation and progression through establishment of a novel genetically engineered mouse m...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Smeester, Branden A., Draper, Garrett M., Slipek, Nicholas J., Larsson, Alex T., Stratton, Natalie, Pomeroy, Emily J., Becklin, Kelsie L., Yamamoto, Kenta, Williams, Kyle B., Laoharawee, Kanut, Peterson, Joseph J., Abrahante, Juan E., Rathe, Susan K., Mills, Lauren J., Crosby, Margaret R., Hudson, Wendy A., Rahrmann, Eric P., Largaespada, David A., Moriarity, Branden S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290861/
https://ncbi.nlm.nih.gov/pubmed/32999043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0369
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