Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm

Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. Preventing α-Synuclein aggregation is challenging because of the disordered nature of the protein and the stochastic nature of fibrillogenesis, but, at the same time, it is a...

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Dettagli Bibliografici
Pubblicato in:Front Bioeng Biotechnol
Autori principali: Peña-Díaz, Samuel, Pujols, Jordi, Pinheiro, Francisca, Santos, Jaime, Pallarés, Irantzu, Navarro, Susanna, Conde-Gimenez, María, García, Jesús, Salvatella, Xavier, Dalfó, Esther, Sancho, Javier, Ventura, Salvador
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Bioengineering and Biotechnology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597392/
https://ncbi.nlm.nih.gov/pubmed/33178678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.588947
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