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α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
α-Synuclein aggregation is a key driver of neurodegeneration in Parkinson’s disease and related syndromes. Accordingly, obtaining a molecule that targets α-synuclein toxic assemblies with high affinity is a long-pursued objective. Here, we exploit the biophysical properties of toxic oligomers and am...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8213730/ https://ncbi.nlm.nih.gov/pubmed/34145261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24039-2 |
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