Hypoxia-Inducible Factor alpha subunits regulate Tie2-expressing macrophages that influence tumor oxygen and perfusion in murine breast cancer

Tie2-expressing monocytes (TEMs) are a distinct subset of pro-angiogenic monocytes selectively recruited to tumors in breast cancer. Due to the hypoxic nature of solid tumors, we investigated if oxygen, via hypoxia inducible transcription factors HIF-1α and HIF-2α, regulates TEM function in the hypo...

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Udgivet i:J Immunol
Main Authors: Steinberger, Kayla J., Forget, Mary A., Bobko, Andrey A., Mihalik, Nicole E., Gencheva, Marieta, Roda, Julie M., Cole, Sara L., Mo, Xiaokui, Hoblitzell, E. Hannah, Evans, Randall, Gross, Amy C., Moldovan, Leni, Marsh, Clay B., Khramtsov, Valery V., Eubank, Timothy D.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596922/
https://ncbi.nlm.nih.gov/pubmed/32938724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000185
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