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Multiplexed probing of proteolytic enzymes using mass cytometry-compatible activity-based probes.

The subset of the proteome that contains enzymes in their catalytically active form can be interrogated by using probes targeted towards individual specific enzymes. A subset of such enzymes are proteases that are frequently studied with activity-based probes, small inhibitors equipped with a detect...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Poreba, Marcin, Groborz, Katarzyna M., Rut, Wioletta, Pore, Milind, Snipas, Scott J., Vizovisek, Matej, Turk, Boris, Kuhn, Peter, Drag, Marcin, Salvesen, Guy S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595764/
https://ncbi.nlm.nih.gov/pubmed/32870676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06762
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