Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model

BACKGROUND: Some patients with cancer treated with anticancer monoclonal antibodies (mAbs) develop antidrug antibodies (ADAs) that recognize and bind the therapeutic antibody. This response may neutralize the therapeutic mAb, interfere with mAb effector function or cause toxicities. We investigated...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Baniel, Claire C, Sumiec, Elizabeth G, Hank, Jacquelyn A, Bates, Amber M, Erbe, Amy K, Pieper, Alexander A, Hoefges, Anna G, Patel, Ravi B, Rakhmilevich, Alexander L, Morris, Zachary S, Sondel, Paul M
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2020
Fag:
Immunotherapy Biomarkers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594540/
https://ncbi.nlm.nih.gov/pubmed/33115944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001262
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker