Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model

BACKGROUND: Some patients with cancer treated with anticancer monoclonal antibodies (mAbs) develop antidrug antibodies (ADAs) that recognize and bind the therapeutic antibody. This response may neutralize the therapeutic mAb, interfere with mAb effector function or cause toxicities. We investigated...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Baniel, Claire C, Sumiec, Elizabeth G, Hank, Jacquelyn A, Bates, Amber M, Erbe, Amy K, Pieper, Alexander A, Hoefges, Anna G, Patel, Ravi B, Rakhmilevich, Alexander L, Morris, Zachary S, Sondel, Paul M
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Immunotherapy Biomarkers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594540/
https://ncbi.nlm.nih.gov/pubmed/33115944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001262
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