Human and murine IL2 receptors differentially respond to the human-IL2 component of immunocytokines

The humanized immunocytokine, hu14.18-IL2 (ICp), leads to the immune cell-mediated destruction of GD2-expressing tumors in mouse models, resulting in potent antitumor effects with negligible IL2-related toxicity. In contrast, when ICp is used clinically, antitumor activity is accompanied by dose-lim...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncoimmunology
Main Authors: Perez Horta, Zulmarie, Saseedhar, Swetha, Rakhmilevich, Alexander L., Carmichael, Lakeesha, Hank, Jacquelyn A., Boyden, Margaret, Gillies, Stephen D., Sondel, Paul M.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492958/
https://ncbi.nlm.nih.gov/pubmed/31069147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1238538
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