TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L

BACKGROUND: Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through the derepression of targets downstream of the mitogen-activated protein kinase (MAPK) signaling cascade, such as oncogenic E26 transformation-specific (ETS) t...

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Udgivet i:BMC Biol
Main Authors: Wong, Derek, Sogerer, Lisa, Lee, Samantha S., Wong, Victor, Lum, Amy, Levine, Adrian B., Marra, Marco A., Yip, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594423/
https://ncbi.nlm.nih.gov/pubmed/33115448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00895-0
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