The majority of β-catenin mutations in colorectal cancer is homozygous

BACKGROUND: β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal studies provide an explanation for this observat...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Arnold, Alexander, Tronser, Moritz, Sers, Christine, Ahadova, Ayel, Endris, Volker, Mamlouk, Soulafa, Horst, David, Möbs, Markus, Bischoff, Philip, Kloor, Michael, Bläker, Hendrik
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594410/
https://ncbi.nlm.nih.gov/pubmed/33115416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07537-2
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