A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia with Sevoflurane

BACKGROUND: Neonatal exposure to sevoflurane induces neurobehavioral and neuroendocrine abnormalities in exposed male rats (generation F0) and neurobehavioral, but not neuroendocrine, abnormalities in their male, but not female, offspring (generation F1). These effects of sevoflurane are accompanied...

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Detalhes bibliográficos
Publicado no:Anesth Analg
Main Authors: Xu, Ning, Lei, Lei, Lin, Yunan, Ju, Ling-Sha, Morey, Timothy E., Gravenstein, Nikolaus, Yang, Jianjun, Martynyuk, Anatoly E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593836/
https://ncbi.nlm.nih.gov/pubmed/32925350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005097
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