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Neonatal Exposure to Sevoflurane Expands the Window of Vulnerability to Adverse Effects of Subsequent Exposure to Sevoflurane and Alters Hippocampal Morphology via Decitabine-Sensitive Mechanisms

BACKGROUND: Deficiencies in neurocognitive function have been found in late childhood or adolescence in patients who had prolonged and/or repeated early-life general anesthesia. Animal studies suggest that anesthetic-induced impairment in the neuron-specific K(+)−2Cl(−) (Kcc2) Cl(−) exporter express...

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Bibliografske podrobnosti
izdano v:Neurosci Lett
Main Authors: Lin, Yunan, Lei, Lei, Ju, Ling-Sha, Xu, Ning, Morey, Timothy E., Gravenstein, Nikolaus, Yang, Jianjun, Martynyuk, Anatoly E.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484112/
https://ncbi.nlm.nih.gov/pubmed/32650051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2020.135240
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