A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia with Sevoflurane

BACKGROUND: Neonatal exposure to sevoflurane induces neurobehavioral and neuroendocrine abnormalities in exposed male rats (generation F0) and neurobehavioral, but not neuroendocrine, abnormalities in their male, but not female, offspring (generation F1). These effects of sevoflurane are accompanied...

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Vydáno v:Anesth Analg
Hlavní autoři: Xu, Ning, Lei, Lei, Lin, Yunan, Ju, Ling-Sha, Morey, Timothy E., Gravenstein, Nikolaus, Yang, Jianjun, Martynyuk, Anatoly E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593836/
https://ncbi.nlm.nih.gov/pubmed/32925350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005097
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