A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia with Sevoflurane

BACKGROUND: Neonatal exposure to sevoflurane induces neurobehavioral and neuroendocrine abnormalities in exposed male rats (generation F0) and neurobehavioral, but not neuroendocrine, abnormalities in their male, but not female, offspring (generation F1). These effects of sevoflurane are accompanied...

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Publicado en:Anesth Analg
Main Authors: Xu, Ning, Lei, Lei, Lin, Yunan, Ju, Ling-Sha, Morey, Timothy E., Gravenstein, Nikolaus, Yang, Jianjun, Martynyuk, Anatoly E.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593836/
https://ncbi.nlm.nih.gov/pubmed/32925350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005097
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