Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells

Human embryonic kidney cells HEK293 can be used for the production of therapeutic glycoproteins requiring human post-translational modifications. High cell density perfusion processes are advantageous for such production but are challenging due to the shear sensitivity of HEK293 cells. To understand...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Zhan, Caijuan, Bidkhori, Gholamreza, Schwarz, Hubert, Malm, Magdalena, Mebrahtu, Aman, Field, Ray, Sellick, Christopher, Hatton, Diane, Varley, Paul, Mardinoglu, Adil, Rockberg, Johan, Chotteau, Veronique
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593556/
https://ncbi.nlm.nih.gov/pubmed/33145483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101653
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