Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells

Human embryonic kidney cells HEK293 can be used for the production of therapeutic glycoproteins requiring human post-translational modifications. High cell density perfusion processes are advantageous for such production but are challenging due to the shear sensitivity of HEK293 cells. To understand...

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Publicat a:iScience
Autors principals: Zhan, Caijuan, Bidkhori, Gholamreza, Schwarz, Hubert, Malm, Magdalena, Mebrahtu, Aman, Field, Ray, Sellick, Christopher, Hatton, Diane, Varley, Paul, Mardinoglu, Adil, Rockberg, Johan, Chotteau, Veronique
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593556/
https://ncbi.nlm.nih.gov/pubmed/33145483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101653
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