Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells

Human embryonic kidney cells HEK293 can be used for the production of therapeutic glycoproteins requiring human post-translational modifications. High cell density perfusion processes are advantageous for such production but are challenging due to the shear sensitivity of HEK293 cells. To understand...

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Xehetasun bibliografikoak
Argitaratua izan da:iScience
Egile Nagusiak: Zhan, Caijuan, Bidkhori, Gholamreza, Schwarz, Hubert, Malm, Magdalena, Mebrahtu, Aman, Field, Ray, Sellick, Christopher, Hatton, Diane, Varley, Paul, Mardinoglu, Adil, Rockberg, Johan, Chotteau, Veronique
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593556/
https://ncbi.nlm.nih.gov/pubmed/33145483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101653
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