The HIV-1 latent reservoir is largely sensitive to circulating T cells

HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus-infected cells. We investigated the patterns of T cell escape variants in the replication-competent reservoir of 25 p...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Warren, Joanna A, Zhou, Shuntai, Xu, Yinyan, Moeser, Matthew J, MacMillan, Daniel R, Council, Olivia, Kirchherr, Jennifer, Sung, Julia M, Roan, Nadia R, Adimora, Adaora A, Joseph, Sarah, Kuruc, JoAnn D, Gay, Cynthia L, Margolis, David M, Archin, Nancie, Brumme, Zabrina L, Swanstrom, Ronald, Goonetilleke, Nilu
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Immunology and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593086/
https://ncbi.nlm.nih.gov/pubmed/33021198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57246
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