GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain

Neuropathic pain is a debilitating public health concern for which novel non-narcotic therapeutic targets are desperately needed. Using unbiased transcriptomic screening of the dorsal horn spinal cord after nerve injury we have identified that Gpr183 (Epstein-Barr virus–induced gene 2) is upregulate...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Braden, Kathryn, Giancotti, Luigino Antonio, Chen, Zhoumou, DeLeon, Chelsea, Latzo, Nick, Boehm, Terri, D’Cunha, Napoleon, Thompson, Bonne M., Doyle, Timothy M., McDonald, Jeffrey G., Walker, John K., Kolar, Grant R., Arnatt, Christopher Kent, Salvemini, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2020
Soggetti:
Drug Discovery and Translational Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592849/
https://ncbi.nlm.nih.gov/pubmed/32913007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000105
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