GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

Treating neuropathic pain is challenging and novel non–opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the s...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Yosten, Gina L.C., Harada, Caron M., Haddock, Chris, Giancotti, Luigino Antonio, Kolar, Grant R., Patel, Ryan, Guo, Chun, Chen, Zhoumou, Zhang, Jinsong, Doyle, Timothy M., Dickenson, Anthony H., Samson, Willis K., Salvemini, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Concise Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190928/
https://ncbi.nlm.nih.gov/pubmed/31999650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133270
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