GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

Treating neuropathic pain is challenging and novel non–opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the s...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Yosten, Gina L.C., Harada, Caron M., Haddock, Chris, Giancotti, Luigino Antonio, Kolar, Grant R., Patel, Ryan, Guo, Chun, Chen, Zhoumou, Zhang, Jinsong, Doyle, Timothy M., Dickenson, Anthony H., Samson, Willis K., Salvemini, Daniela
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Concise Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190928/
https://ncbi.nlm.nih.gov/pubmed/31999650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133270
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