Developing Genome-wide Polygenic Risk Scores for Coronary Artery Disease in South Asians

BACKGROUND: Genome-wide polygenic scores (GPS) integrate information from many common DNA variants into a single number. Because rates of coronary artery disease (CAD) are substantially higher among South Asians, a GPS to identify high-risk individuals may be particularly useful in this population....

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Vydáno v:J Am Coll Cardiol
Hlavní autoři: Wang, Minxian, Menon, Ramesh, Mishra, Sanghamitra, Patel, Aniruddh P., Chaffin, Mark, Tanneeru, Deepak, Deshmukh, Manjari, Mathew, Oshin, Apte, Sanika, Devanboo, Christina S, Sundaram, Sumathi, Samson, Praveena L, Murugan, Sakthivel, Sharma, Krishna Kumar, Karthikeyan, R, Santhosh, Sam, Thachathodiyl, Rajesh, Ahamed, Hisham, Balegadde, Aniketh Vijay, Alexander, Thomas, Swaminathan, Krishnan, Gupta, Rajeev, Mullasari, Ajit S, Sigamani, Alben, Kanchi, Muralidhar, Peterson, Andrew S., Butterworth, Adam S, Danesh, John, Angelantonio, Emanuele Di, Naheed, Aliya, Inouye, Michael, Chowdhury, Rajiv, Ramprasad, Vedam L, Kathiresan, Sekar, Gupta, Ravi, Khera, Amit V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592606/
https://ncbi.nlm.nih.gov/pubmed/32762905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2020.06.024
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