p27 Allosterically Activates Cyclin-Dependent Kinase 4 and Antagonizes Palbociclib Inhibition

The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). Under some circumstances p27 is associated with active CDK4, but no mechanism for activation has been described. We found that p27, when phosphorylated by tyrosin...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Science
Päätekijät: Guiley, Keelan Z., Stevenson, Jack W., Lou, Kevin, Barkovich, Krister J., Kumarasamy, Vishnu, Wijeratne, Tilini U., Bunch, Katharine L., Tripathi, Sarvind, Knudsen, Erik S., Witkiewicz, Agnieszka K., Shokat, Kevan M., Rubin, Seth M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592119/
https://ncbi.nlm.nih.gov/pubmed/31831640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw2106
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