Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30, isolated from a patient infected with SARS-CoV-2, in complex with the receptor binding domain. The structure reveals that CV...

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Foilsithe in:Nat Commun
Main Authors: Hurlburt, Nicholas K., Seydoux, Emilie, Wan, Yu-Hsin, Edara, Venkata Viswanadh, Stuart, Andrew B., Feng, Junli, Suthar, Mehul S., McGuire, Andrew T., Stamatatos, Leonidas, Pancera, Marie
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591918/
https://ncbi.nlm.nih.gov/pubmed/33110068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19231-9
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