Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we determined the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30, isolated from a patient infected with SARS-CoV-2, in complex with the receptor binding domain (RBD). The structure reveals...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:bioRxiv
Main Authors: Hurlburt, Nicholas K., Wan, Yu-Hsin, Stuart, Andrew B., Feng, Junli, McGuire, Andrew T., Stamatatos, Leonidas, Pancera, Marie
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301900/
https://ncbi.nlm.nih.gov/pubmed/32577631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.12.148692
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