Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 da...

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Udgivet i:Immunity
Main Authors: Seydoux, Emilie, Homad, Leah J., MacCamy, Anna J., Parks, K. Rachael, Hurlburt, Nicholas K., Jennewein, Madeleine F., Akins, Nicholas R., Stuart, Andrew B., Wan, Yu-Hsin, Feng, Junli, Whaley, Rachael E., Singh, Suruchi, Boeckh, Michael, Cohen, Kristen W., McElrath, M. Juliana, Englund, Janet A., Chu, Helen Y., Pancera, Marie, McGuire, Andrew T., Stamatatos, Leonidas
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276322/
https://ncbi.nlm.nih.gov/pubmed/32561270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.06.001
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