Tetrahydroimidazo[1,2‐a]pyrazine Derivatives: Synthesis and Evaluation as Gα(q)‐Protein Ligands

The 5,6,7,8‐tetrahydroimidazo[1,2‐a]pyrazine derivative BIM‐46174 and its dimeric form BIM‐46187 (1) are heterocyclized dipeptides that belong to the very few cell‐permeable compounds known to preferentially silence Gα(q) proteins. To explore the chemical space of Gα(q) inhibitors of the BIM chemoty...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Küppers, Jim, Benkel, Tobias, Annala, Suvi, Kimura, Kenichi, Reinelt, Lisa, Fleischmann, Bernd K., Kostenis, Evi, Gütschow, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7590114/
https://ncbi.nlm.nih.gov/pubmed/32428383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001446
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados