Reduction of CD11b(+) myeloid suppressive cells augments anti-neuroblastoma immune response induced by the anti-GD(2) antibody ch14.18/CHO

Neuroblastoma (NB) still remains a major challenge in pediatric oncology. We recently showed CD11b(+)-dependent upregulation of the PD-1/PD-L1 checkpoint on NB cells treated with the chimeric anti-GD(2) antibody (Ab) ch14.18/CHO. Here, we report effects of reduction of CD11b(+) myeloid suppressive c...

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Publicado en:Oncoimmunology
Autores principales: Siebert, Nikolai, Zumpe, Maxi, von Lojewski, Leon, Troschke-Meurer, Sascha, Marx, Madlen, Lode, Holger N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588217/
https://ncbi.nlm.nih.gov/pubmed/33150046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1836768
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